Curr Biol：分散注意力可有效纾缓疼痛感

亦同，发表在国际都曾杂志Cell的子刊Current Biology上的一篇建议书指出新，利用焦虑不良影响（偏偏）的原理可以使得痛楚加大，然而这种痛楚缓解加大的效应并不一定表现在四肢。这项学术研究推断出新是基于使用高分辨率的骨髓功能性磁共振成像新技术（fMRI新技术），对人们由于高温引发的痛楚水平透过学术研究，学术研究说明了，焦虑不良影响显然可以在中枢痛楚处理现代抑制痛楚信号的盛行。来自汉堡-埃庞多夫大学医学院的学者Christian Sprenger问到，这种现象并不一定仅仅是一种焦虑现象，而是一种活跃的神经细胞机制，可以增大从脊髓持续上升至大脑Senior周围的痛楚信号。

这种效应牵涉到到了内源性的类物质，这种物质产生自大脑，在加大痛楚的过程中起着重要脚色。学术研究人员让组织者分别未完成一个简单或者一个不易的记忆性任务，必须他们记住信件的文字内容，同时给组织者手脚上施予高温。透过不易任务的组织者越发心烦意乱时，他们会无法忍受较小的痛楚，通过fMRI新技术揭示出新这些组织者的脊髓周围活性越发非常低，fMRI往往是用来测定大脑活性的忽略。

Sprenger和他的合作者然后重复了测试，这次他们给予组织者一种类固醇-钠洛酮（抗休克的理想类固醇，可以阻挡类类固醇的效应）或者都是的清水流入，整体而言，相比只流入都是清水的组织者，使用类类固醇阿司匹林的组织者由于注意力分散，引发的痛楚缓解增大了40%，因此表明内源性的起着重要起到。

学者的推断出新说明了了焦虑过程可以深入地忽略人们的痛楚历程，并且对于临床也有极其重要的意义。学者问到，我们的学术研究推断出新给痛楚疾病治疗提供了认知不当治疗的原理。（生物谷：T.ShenPHP）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.